secobarbital will minimize the level or effect of felodipine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.secobarbital will decrease the extent or effect of levonorgestrel intrauterine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.Revision of the OED can be a long-term challenge. Entr